Breast Cancer Clinical Trials in Men

Some people with #cancer will have only one #treatment. But most people have a combination of treatments, such as surgery with #chemotherapy and/or #radiation #therapy. When you need treatment for cancer, you have a lot to learn and think about.

Graft Guidance is issued by US #FDA encouraging the inclusion of male patients in #clinical #trials of breast cancer drugs. #Breast_cancer is rare in males, with less than 1% of all cases occurring in men. Men are not typically included in #clinical_trials for breast cancer treatment, which has led to a related lack of data. Men's treatments are generally based upon studies in #women, said the FDA in a press statement. Some approved treatments are gender-neutral in their indication, but many therapies are only approved for women and further data may be necessary to support labeling indications for men, the agency pointed out. The goal of the guidance is to provide additional #FDA-approved treatment options for men.

Recently, the FDA extended the indication of the breast cancer drug #palbociclib to include male patients, based on "real world" data. Post marketing reports and electronic health records showed that the safety profile for men treated with palbociclib was consistent with the safety profile for women. The decision was also based on the acknowledgement that the majority of breast tumors in male patients express hormone receptors; such #tumors are typically treated with endocrine-based therapies, which, in #advanced_cancers, may include palbociclib.

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Breast_Cancer_Congress_2020 #Conference

Breast cancer is caused by a genetic mutation in the DNA of breast cancer cells. How or why this damage occurs isn’t entirely understood. Some mutations may develop randomly over time, while others are inherited or may be the result of environmental exposures or lifestyle factors. Most breast cancers are diagnosed in women over age 50, but it’s not clear why some women get breast cancer (including women with no risk factors) and others do not (including those who do have risk factors). Breast cancer symptoms vary from one person to the next. Knowing what your breasts normally look and feel like may help you recognize possible signs and symptoms. By 2025, an estimated 2.1 million people in the United States will be diagnosed with cancer every year. This is a 31-percent increase from 2012 that is due in part to the aging of the U.S. population and the greater use of cancer screening. The estimated number of annual cancer-related deaths is expected to increase even faster, by 37 percent, from 620,000 to 850,000 by 2025.

Register for the scientific sessions @ #Breast_Cancer_Congress_2020 #Conference during #June 15-17 @ #Zurich #Switzerland   #Breast-Cancer-Risk-Factors #Awareness #Breast #Cancer #Therapies #conference & kindly submit #abstract for #Oral/#poster sessions #breast_cancer_patients #breast_cancer_research_and_treatment #breast_cancer_survival #breast_cancer_risk #breast_cancer_conference #Mammograms #Mastectomy #chemotherapy

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Breast Cancer Surgery

Most women with breast cancer have some type of surgery as part of their treatment. There are different types of #breast_surgery, and it may be done for different reasons, depending on the situation. 

For example, surgery may be done to:

·        Remove as much of the #cancer as possible (#breast-conserving surgery or #mastectomy)

·        Find out whether the cancer has spread to the lymph nodes under the arm (sentinel lymph node biopsy or axillary lymph node dissection)

·        Restore the breast’s shape after the cancer is removed (#breast_reconstruction)

·        Relieve symptoms of #advanced #cancer

There are two main types of surgery to remove breast cancer:

Breast-conservingsurgery also called a #lumpectomy, #quadrantectomy, partial #mastectomy, or segmental mastectomy) – A surgery in which only the part of the breast containing the cancer is removed. The goal is to remove the cancer as well as some surrounding normal tissue. How much of the breast is removed depends on the size and location of the tumor and other factors.

#Mastectomy – A surgery in which the entire breast is removed, including all of the breast tissue and sometimes other nearby tissues. There are several different types of #mastectomies. Some women may also get a double mastectomy, in which both breasts are removed. Cancer cells might have spread into the lymph nodes close to the breast. #Lymph nodes are found in many parts of the body. They filter out #bacteria and damaged cells from the lymphatic fluid, and contain cells that fight infection.

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Breast Cancer: Present Perspective

Breast cancer is the most common cancer among women. Symptoms include a lump or thickening of the breast, and changes to the skin or the nipple. Substantial support for breast cancer awareness and research funding has helped created advances in the diagnosis and treatment of breast cancer. Triple-negative breast cancer is another rare disease type, affecting only about 10 to 20 percent of people with breast cancer. Breast cancer can also develop in men, but which is rare. Breast cancer develops from a cancerous cell which develops in the lining of a mammary duct or a lobule in one of the breasts. It follows the classic progression though it often becomes systemic or widespread in the early onset of the disease. During this period, the cancer may metastasize, or spread through lymphatics or blood stream to areas elsewhere in the body. If breast cancer spreads to vital organs of the body, its presence will compromise the function of those organs. Fatal death is the result of extreme case of vital organ function.

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Breast Cancer Nursing

Breast cancer is the most common cancer in women and the second leading cause of cancer deaths. The risk of breast cancer increases with age. About 77% of women with breast cancer are older than age 50 at diagnosis. Persons at high risk include those who carry or develop certain genetic mutations and those with a family history of breast cancer.

Studying about breast cancer nursing will provide us with the principles of breast cancer nursing in order to improve our knowledge and skills for the provision and coordination of evidenced based breast cancer care. Some women, whether due to family history, genetic tendencies, and/or other factors, can be considered high risk for cancer development and should be screened with MRIs as early as age 30. Though this is said to be a small number of patients, guidelines also state that those women who do undergo MRI screening should do so in addition to a mammogram because an MRI could miss some cancers that a mammogram would detect even though they are more likely to detect cancer than a mammogram.

U.S. Food and Drug Administration also expanded the approved use of Lynparza to include the treatment of patients living with certain types of breast cancer that have spread and whose tumors have a specific inherited genetic mutation, making it the first drug in its class (poly ADP ribose polymerase inhibitor) approved to treat breast cancer.

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Study says Breast cancer cells could be turned into fat to stop them from spreading

A scientific breakthrough may give many women suffering from breast cancer a new ray of hope after a group of researchers at the University of Basel in Switzerland said that they have successfully transformed breast cancer cells into fat — “rendering them harmless, and stopping the disease from moving to other parts of the body.

The researchers took mice implanted with an aggressive form of human breast cancer, and treated them with both a diabetic drug called rosiglitazone and a cancer treatment called trametinib. The team said they exploited a weird pathway that metastasizing cancer cells have. When one cuts their finger, or when a foetus grows organs, the epithelium cells begin to look less like themselves, and more ‘fluid’ – changing into a type of stem cell called a mesenchyme and then reforming into whatever cells the body needs.

This process is called epithelial-mesenchymal transition (EMT) and it’s been known for a while that cancer can use both this and the opposite pathway called MET (mesenchymal-to-epithelial transition), to spread throughout the body and metastasize. When cancer cells used one of the above-mentioned transition pathways, instead of spreading, they changed from cancer into fat cells – a process called adipogenesis.

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Switching red meat for poultry may lower breast cancer risk

Replacing red meat with poultry may lower the risk for breast cancer, according to study results published in the International Journal of Cancer.

The prospective analysis, in the International Journal of Cancer, included 42,012 women who provided health and diet data for a national study of breast cancer. Researchers followed them for an average of seven and a half years. Compared with those in the lowest one-fourth for meat consumption, those in the highest one-quarter were 23 percent more likely to develop invasive cancer; those in the highest one-quarter for white meat consumption were 15 percent less likely to develop it than those in the lowest quarter. The associations were stronger for breast cancer that arose after menopause. The study controlled for age, physical activity, body mass index, calorie consumption and other diet and health characteristics.

Eating less red meat and more chicken significantly reduces a woman’s odds of developing aggressive breast cancer, researchers have found. Women who eat a lot of meat could cut their risk of invasive breast cancer by 28 percent if they replaced it with poultry, the study suggests.
After exclusions, 42,012 women with a mean 7.6 years of follow up were included in analyses. A total of 1,536 cases of invasive breast cancers were diagnosed more than a year after enrolling in the study. Results from a substitution model showed that the risk for invasive breast cancer decreased when the same amount of meat was consumed, but red meat was substituted with poultry.

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#Breast_cancer_Types #Invasive #Ductal_Carcinoma #Breast #Colloid_Carcinoma #Milk_Duct #Mucus #Physical_Exam #Ultrasound #Mammogram #MRI #Biopsy

#Breast_cancer is the most frequently diagnosed life-threatening #cancer in women and the leading cause of cancer death among women. The most common types are #ductal_carcinoma in situ, #invasive_ductal_carcinoma, and #invasive_lobular_carcinoma. Most breast cancers are #carcinomas. Carcinomas are #tumors that start in the #epithelial cells that line organs and tissues throughout the body. There are other, less common, types of breast cancers, too, such as sarcomas, phyllodes, Paget disease, and #angiosarcomas which start in the cells of the muscle, fat, or connective tissue.

There are many types of breast cancer, some of them include:

·       Ductal Carcinoma in situ. Ductal Carcinoma in Situ is a non-invasive breast cancer where abnormal cells have been contained in the lining of the breast milk duct.

·       Invasive Ductal Carcinoma.

·       Triple Negative Breast Cancer.

·       Inflammatory Breast Cancer.

·       Metastatic Breast Cancer.

·       Breast Cancer during Pregnancy.

·       Other Types.

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Breast Cancer Congress 2020

Frontiers Meetings welcomes you to “Global Experts Meeting on Frontiers in Breast Cancer” Scheduled during June 15-17, 2020 in Zurich, Switzerland.

Breast Cancer Congress 2020 conference in Zurich, Switzerland has been designed in an interdisciplinary manner with a multitude of tracks to choose from every segment and provides you with a unique opportunity to meet up with peers from both industry and academia and establish a scientific network between them. We cordially invite all concerned people to come join us at our event and make it successful by your participation.

Breast Cancer Congress 2020 is one of the largest international meetings on Breast Cancer and Therapies. With more than 100 Radiologists, Radiation Oncologists, Radiation Therapists, Medical Oncologists and Breast Care Nurses along with researchers, educators, administrators, policy makers and students expected to attend the conference. Breast Cancer Congress 2020 promises to be an exciting and rewarding opportunity to learn together.

We are honored to host high-profile keynote speakers from around the world as well as many concurrent oral and poster presentations i.e. robust scientific programs on key health issues and advances in Breast Cancer and Therapies from conference participants. We seek to provide a highly enthusiastic ambiance for exploring and unveiling the Research, Business and Edu-tech oriented skills to our global attendees.